BTEC Introduction to Chemical Modification of Protein Therapeutics
Date and Time
Tuesday Sep 7, 2021 Friday Sep 10, 2021
September 7 - 10
This course features two live discussion sessions/workshops. These will be led by the instructors via Zoom on the following dates:
- Tuesday, Sept. 7, 1:00–2:00 p.m. EDT – This session provides an introduction to the course, its instructors, and the website hosting the self-paced lecture materials. The session also defines and establishes the importance and benefits of chemically modified protein therapeutics.
- Friday, Sept. 10, 8:30 a.m.–12:30 p.m. EDT – This session focuses on process optimization and provides participants with the opportunity to apply their knowledge of chemical modifications, protein chemistry, modification benefits and techniques, and manufacturing and analytical/characterization methods. Participants will work through and discuss an example of chemical reaction parameters for a specific modification and its purification, characterization, and troubleshooting. Ample time will be provided for questions.
- Note! Because this live session emphasizes active participation and discussion, participants are expected to complete the on-demand modules in advance.
Important: To ensure the privacy of participants, live sessions will NOT be recorded. Therefore, participants unable to attend at the dates and times specified will miss those sessions.
Location
Zoom
Fees/Admission
$1,375
Website
Contact Information
Melody Woodyard, NCSU
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Description
Chemical modifications of protein therapeutics are common across approved drugs. Numerous examples exist, including PEGylated protein therapeutics, which have polyethylene glycol (PEG) chains attached to the protein to increase the systemic half-life in the body. In addition, there are a number of antibody-drug conjugates (ADCs) on the market that consist of an anti-cancer agent linked to an antibody for targeted delivery of the agent to a specific tumor.
This online course provides participants an understanding of important modification methods applied to protein therapeutics. It offers a unique opportunity to learn about the processes, analytical methods, and regulatory considerations for the design and execution of GMP processes for chemically modified biopharmaceuticals.
